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. 2021 Oct 1;10(10):2618. doi: 10.3390/cells10102618

Figure 2.

Figure 2

Nlrp3−/− mice developed less liver damage and fibrosis after DCA feeding. Intermediate liver damage after DCA feeding was ameliorated in Nlrp3−/− mice as indicated by H&E staining (A) and lower transaminase levels (E). Nlrp3−/− mice show reduced Caspase-1 activity and Il-1b mRNA levels (B,F), resulting in attenuated fibrotic alterations as shown in SiriusRed stained liver sections (D) and decreased mRNA levels of fibrotic markers (αSma, Ctgf, Col1a1) (H). Nlrp3−/− did not affect MPO positive cells and mRNA levels of F4/80, Cd68, Mcp1, Tnf, iNOS and IL-18 as markers of immune cells invasion (C,G). * p < 0.05; ** p < 0.01; n.d.: not detected; n = 6.