Figure 1.

Identification of driver mutations and additional somatic mutations in myeloproliferative neoplasms by modern sequencing technologies. The advent of modern sequencing technologies over the last two decades has led to the characterization of the genetic landscape in myeloproliferative neoplasms (MPN), including driver mutations (*) in JAK2, MPL, and CALR genes as well as concomitant somatic mutations in cancer genes frequently mutated in myeloid malignancies. Mutations in the genes highlighted in bold are considered of “high molecular risk” (HMR) given their adverse prognostic impact. The year of discovery of specific mutations is indicated as well as the development of sequencing methodologies over time.