Figure 2.

Prognostic scoring systems for myelofibrosis. Early prognostication schemes for myelofibrosis relied on clinical factors including age, hematologic parameters including cytopenias and blast count, and symptoms, while more recent scores have increasingly implemented genetic factors such as information on cytogenetic features, driver mutations, and concomitant somatic mutations of prognostic impact. IPSS: international prognostic scoring system, DIPSS: dynamic international prognostic system, MYSEC: myelofibrosis secondary to PV and ET-prognostic model, MIPPS70: mutation-enhanced international prognostic score system (validated up to 70 years of age), GIPSS: genetically inspired prognostic scoring system.