Figure 1.

Signals from tissue damage and inflammatory cells may trigger the process of repair. Neural precursor cells (NPCs) proliferate from SVZ and migrate to the perihematomal area and differentiate into neurons and glia, contributing to brain restoration. However, most of these NPCs could not survive more than 3 weeks due to extensive apoptosis. Moreover, the proliferated Olig2⁺ cells were preferentially gathered inside the white matter bundles, although there are no data on whether these newly formed oligodendrocytes contribute to subsequent remyelination. Inflammatory products from resident and infiltrated immune cells promote or hinder tissue recovery according to their phenotypes.