Table 1.
Potential strategies to promote tissue regeneration after intracerebral hemorrhage.
| Approaches | Possible Benefits | |
|---|---|---|
| Medications | Statins | Neurogenesis, angiogenesis, phagocytosis |
| Minocycline | “M2” polarization, neurogenesis | |
| Fingolimod/Siponimod | Neurogenesis, remyelination | |
| Lithium | Trophic factors, white matter repair | |
| CD47 antibody | Hematoma clearance | |
| Stem cells | BM-MSCs | Axonal regeneration, BBB reconstruction |
| Muse cells | Cell replacement of neurons | |
| ADSCs | Neuron-like differentiation, VEGF | |
| UCSCs | Neurogenesis, angiogenesis, remyelination | |
| Exosomes | Remyelination, axonal sprouting, neurogenesis | |
| Biomaterials | Hydrogel | Regulatory polarization, neurogenesis |
| SAPNS | Oligodendrogenesis, remyelination | |
| Rehabilitation | Skilled reach training | Dendritic reorganization, BDNF |
| Enriched environment | Dendritic length | |
| Acrobatic training | Neuronal activity, synaptic remodeling | |
| Aerobic training | Dendritic length and complexity |