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. 2021 Oct 4;10(10):2652. doi: 10.3390/cells10102652

Figure 4.

Figure 4

Tp63 isoforms. (A) TAp63 and ΔNp63 with α, β, γ, δ, ε splice variant isoforms. TA: transactivation domain; TA’: N-terminally truncated transactivation domain; DBD: DNA binding domain; OD: oligomerization domain; TA2: second transactivation domain; SAM: sterile alpha motif; ID: inhibitory domain. (B) Schematic representation of the P63 gene exon organization. Alternative promoters induce the synthesis of TAp63 (P1 promoter) or ΔNp63 (P2 promoter). α, β, γ, δ, ε splice variant isoforms are generated upon alternative splicing in C-terminal region. Alternatively, spliced forms for exon 10 are indicated as 10′ and 10″. Exon numbering is indicated. The exon color code corresponds to protein domains. Adapted from Vanbokhoven, Melino et al. 2011 [81].