Skip to main content
. 2021 Oct 4;10(10):2652. doi: 10.3390/cells10102652

Figure 5.

Figure 5

USP28 stabilizes ∆Np63 enhancing SCC cell identity, oncogenesis, proliferation, cell cycle progression and genomic stability. (A) Ubiquitously, USP28 regulates the stability of several oncoproteins involved in proliferation, cell cycle progression and oncogenesis, such as c-MYC, c-JUN, NOTCH1 or CCNE (B) In SCC tumors, USP28 regulates the oncoproteins indicated in (A) but also ∆Np63. ∆Np63 strongly regulates SCC cell identity, oncogenesis, proliferation, cell cycle progression and genomic stability. Ub = ubiquitin.