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. 2021 Oct 4;10(10):2652. doi: 10.3390/cells10102652

Figure 7.

Figure 7

Models proposed for USP28 substrate recognition. (A) Model 1: An E3-ligase is required for USP28 substrate recognition. USP28 only stabilizes proteins upon the formation of a complex with the E3-ligase. (B) Model 2: USP28 deubiquitinates substrates independently of E3-ligases. (C) Model 3: Unphosphorylated USP28 acts as (A) (model 1). Upon DNA damage or replication stress, the phosphorylated USP28 on serine 67 and serine 714 acts as (B) (model 2). Ub = ubiquitin; p = phosphorylation; S = serine.