Table 1.

Regulators of USP28.

Regulator:	Positive or Negative Regulation:	Effect on USP28:	REF.:
ATM	Positive	Phosphorylates USP28 increasing its activity	[10]
CASPASE 8	Negative	Cleaves and inactivates USP28	[18]
SENP1	Positive	Desumoylates USP28 increasing its activity	[14]
HDAC5	Positive	Increases USP28 stability blocking its polyubiquitination	[19]
miR-92b-3p	Negative	Reduces USP28 translation	[22]
miR-216b	Negative	Reduces USP28 translation	[23]
mi-R3940-5p	Negative	Reduces USP28 translation	[25]
miR-500a-5p	Negative	Reduces USP28 translation	[24]
Circ-FBXW7	Negative	Reduces USP28 substrate recognition decreasing its activity	[26]
c-JUN	Positive	Increases USP28 transcription	[20]
c-MYC	Positive	Increases USP28 transcription	[21]