Table 2.

USP28 protein targets.

Target:	USP28 Effect:	USP28 Cancer Function:	REF.:
c-MYC	Increases its stability	Oncoprotein	[21,27,33,34,39,40]
FBXW7	Increases its stability	Tumor suppressor	[34]
c-JUN	Increases its stability	Oncoprotein	[21,33,34]
NOTCH1	Increases its stability	Oncoprotein	[21,33,34]
CLASPIN	Increases its stability	Oncoprotein or tumor suppressor dependent on cellular context	[38]
CHK2	Increases its stability	Tumor suppressor	[10,36]
53BP1	Increases its stability	Tumor suppressor	[10]
MDC1	Increases its stability	Tumor suppressor	[10]
LSD1	Increases its stability	Oncoprotein	[19,41]
HIF-1a	Increases its stability	Oncoprotein or tumor suppressor dependent on cellular context	[14,42]
CCNE	Increases its stability	Oncoprotein	[21,33,34]
H2A	Enhances transcriptional activation	Tumor suppressor	[43]
∆Np63	Increases its stability	Oncoprotein	[17]
p53	Increases its stability	Tumor suppressor	[18,44,45,46]
UCK1	Increases its stability	Tumor suppressor	[47]
STAT3	Increases its stability	Oncoprotein	[48]
ZNF304	Increases its stability	Oncoprotein	[20]
LIN28A	Increases its stability	Oncoprotein	[49]
FOXC1	Increases its stability	Oncoprotein	[50]
MTOR	Increases its stability	Oncoprotein	[34]
MCL1	Increases its stability	Oncoprotein	[34]
CD44	Increases its stability	Oncoprotein	[51,52]