Table 1.

List of miRNAs with therapeutic potential for UM, identified in preclinical studies.

miRNA	Preclinical Studies	Function	Target(s)	Ref.
miR-21-3p (oncomiR)	OCM-1 cells stably transfected with miR-21-3p inhibition vector s.c. injected into the right side of the axilla in nude mice	Reduces in vivo UM tumor growth	p53 and LASP1	[54]
Let-7b	OCM-1 cells stably overexpressing let-7b s.c. injected into the right flank in thymic nude mice	Increases radiosensitivity of UM cells	Cyclin D1	[55]
miR-17-3p	OCM-1A cells transfected with miR-17-3p agomir s.c. injected into the left axilla in nude mice	Suppresses tumorigenesis and metastasis of UM	MDM2	[56]
miR-124a	M23 cells or SP6.5 cells expressing miR-124a s.c. inoculated into the flank in nude mice	Suppresses UM tumor growth in vivo and inhibits UM cell invasion	CDK4/6, cyclin D2 and EZH2	[59]
miR-142-3p	miR-142-3p-transfected SP6.5 or M17 cells inoculated into the suprachoroidal space in nude mice	Inhibits cell proliferation, migration and invasion	CDC25C, TGFβR1, GNAQ, WASL and RAC1	[48]
miR-145	Lentivirus-miR-145-transduced OCM-1 cells s.c. injected in the right side of the axilla in nude mice	Reduces xenograft tumor growth and angiogenesis	IRS-1, N-RAS and VEGF	[63]
miR-182	M23 or SP6.5 cells expressing miR-182 s.c. inoculated into the flanks of nude mice	Suppresses in vivo UM growth	MITF, BCL2 and cyclin D2	[64]