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miR-146b/Fas ligand axis. (A) miR-146b normal expression prevents HuR translation, leading to FasL mRNA degradation. (B) STAT3-mediated miR-146b defective expression allows HuR mRNA translation, leading to increased FasL expression by leukemic T-LGL. FasL, Fas ligand; HuR: human antigen R; s-FasL: soluble Fas ligand; miR-146b, micro-RNA 146b; mRNA, messenger RNA; STAT3: signal transducer and activator of transcription 3.
