Table 1.

Workup for unknown bone lesion in patients >40 years old.

Laboratory	Tests	Notes
	Complete Blood Count
	Electrolyte panel
	Bone biochemistry
	Liver Function Tests
	Thyroid function tests
	Prostate specific antigen
	Inflammatory Markers
	Serum protein electrophoresis/Urine protein electrophoresis
Imaging	Orthogonal radiographs	Full length of affected bone and contralateral side
	Whole body bone scan
	CT chest, abdomen, pelvis
	Cross-sectional imaging of involved extremity	MRI or CT depending on patient factors
Biopsy	Open or image-guided	Follow biopsy principles