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Discordant PD-L1 reactivity in paired histological and cytological specimens from a lung adenocarcinoma (original magnification ×400). (A) Transthoracic core biopsy, H&E staining, >500–1000 cells. (B) Transthoracic core biopsy, PD-L1 immunostaining, ≥5% positive malignant cells. (C) Pleural effusion, H&E staining, 100–300 cells. (D) Pleural effusion, PD-L1 immunostaining, ≥50% positive malignant cells.
