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. 2021 Oct 12;10(10):2724. doi: 10.3390/cells10102724

Figure 6.

Figure 6

Re-expression of IQSEC2 in the mPFC rescues social behaviors. (A) Summary graph for interaction with a free-moving juvenile mouse in wild-type and IQSEC2 KO mice infected with control AAV (WT Control and KO Control), and IQSEC2 KO mice infected with IQSEC2 AAV (KO Rescue). Interaction with a juvenile mouse is restored in the KO rescue mice. (B) Experimental diagram (top), heatmap images (middle), and summary graphs (bottom) for social preference test in wild-type infected with control AAV (WT Control), IQSEC2 KO infected with control AAV (KO Control), and IQSEC2 KO mice infected with IQSEC2 AAV (KO Rescue). Preference for stranger mouse (S1) is restored in KO Rescue mice. (C) Experimental diagram (top), heatmap images (middle), and summary graphs (bottom) for social novelty preference test in wild-type infected with control AAV (WT Control), IQSEC2 KO infected with control AAV (KO Control), and IQSEC2 KO mice infected with IQSEC2 AAV (KO Rescue). Preference for a new stranger mouse (S2) is restored in KO Rescue mice. Data are means ± SEM (numbers of animals examined are shown in graphs). Statistical analyses were performed by One-way ANOVA followed by Tukey’s post-hoc test in A, Student’s t-test in B and C (time spent around cup), One-way ANOVA followed by Tukey’s post-hoc test in B and C (preference index). *p < 0.05; **p < 0.01; n.s. = not significant. Data values used in graphs are shown in Table S2.