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Main effects of sildenafil according to preclinical models of brain injury from neonatal to adult rodents. HI: hypoxia-ischemia; TBI/Cryo: traumatic brain injury/cryolesion.
| Effect | Neonatal | Juvenile | Adult | |
|---|---|---|---|---|
| HI | TBI/Cryo | |||
| CBF | +++ | + | + | ? |
| Angiogenesis | +/−? | + | + | + |
| Inflammation | +++ | |||
| Cell death | ++ | ++ | ++ | + |
| Neurogenesis | + | ++ | ++ | ? |
