Table 1.
Clinical and Radiologic Variables Stratified by PRM Indices
| All (N = 61) | PRMNormal (n = 29) | PRMfSAD ⩾30% (n = 7) | PRMPD ⩾30% (n = 25) | P Value* | |
|---|---|---|---|---|---|
| HRCT variables, n (%) | |||||
| Air trapping | 40 (66) | 18 (62) | 4 (57) | 18 (72) | 0.27 |
| Mild | 19 (31) | 8 (28) | 2 (29) | 9 (36) | 0.86 |
| Moderate | 19 (31) | 9 (31) | 2 (29) | 8 (32) | 1.0 |
| Severe | 2 (3) | 1 (3) | 0 (0) | 1 (4) | 1.0 |
| Ground-glass opacities | 10 (16) | 2 (7) | 0 (0) | 8 (32) | 0.03 |
| Nodularity | 22 (36) | 7 (24) | 4 (57) | 11 (44) | 0.15 |
| Consolidation | 7 (11) | 1 (3) | 1 (14) | 5 (20) | 0.11 |
| Interstitial changes | 3 (5) | 0 (0) | 0 (0) | 3 (12) | 0.15 |
| Radiologist impression, n (%) | |||||
| BOS | 27 (44) | 11 (38) | 5 (71) | 11 (44) | 0.36 |
| RAS | 3 (5) | 1 (3) | 0 (0) | 2 (8) | 0.72 |
| Infection | 26 (43) | 6 (21) | 4 (57) | 16 (64) | 0.003 |
| Bronchoscopy at potential CLAD, n (%) | 42 (69) | 18 (62) | 5 (71) | 19 (76) | 0.46 |
| Diagnostic transbronchial biopsy at potential CLAD, n (%) | 29 (48) | 13 (45) | 3 (43) | 13 (52) | 0.94 |
| Acute rejection at potential CLAD†, n (%) | 10 (34) | 4 (31) | 1 (33) | 5 (38) | 0.98 |
| Clinical infection at potential CLAD, n (%) | 24 (39) | 8 (28) | 4 (57) | 12 (48) | 0.18 |
| BMI at potential CLAD, kg/m2, mean (SD) | 27.4 (5.35) | 28.4 (4.06) | 23.1 (7.14) | 27.4 (5.74) | 0.06 |
Definition of abbreviations: BMI = body mass index; BOS = bronchiolitis obliterans syndrome; CLAD = chronic lung allograft dysfunction; fSAD = functional small airway disease; HRCT = high-resolution computed tomography; PD = parenchymal disease; PRM = parametric response mapping; RAS = restrictive allograft syndrome.
*
Fisher exact test.
†
Acute rejection at potential CLAD indicates patient had a transbronchial biopsy that showed any grade of type A or B acute rejection. The denominator is number of diagnostic transbronchial biopsies in that group.