Table 2.
Multivariable Restricted Mean Analysis Evaluating Impact of Clinical and PRM Variables on Survival
| Estimate* | Lower Bound | Upper Bound | P Value | |
|---|---|---|---|---|
| Intercept | 485.2 | 282.6 | 833.3 | <0.001 |
| PRMfSAD ⩾30% | 0.410 | 0.224 | 0.751 | 0.004 |
| PRMPD ⩾30% | 0.542 | 0.295 | 0.998 | 0.049 |
| Single-lung transplant | 1.133 | 0.677 | 1.896 | 0.634 |
| Age at transplant (10-yr unit, centered at 49 yr old) | 0.996 | 0.984 | 1.008 | 0.512 |
| Transplant to CT scan (yr, centered at 1 yr) | 1.133 | 1.055 | 1.217 | <0.001 |
| BMI at potential CLAD (centered at 22 kg/m2) | 1.049 | 1.007 | 1.092 | 0.022 |
Definition of abbreviations: BMI = body mass index; CT = computed tomography; CLAD = chronic lung allograft dysfunction; fSAD = functional small airway disease; PD = parenchymal disease; PRM = parametric response mapping.
*
Estimate for intercept reflects the estimated CLAD-free survival over 5 follow-up years for a 49-year-old lung transplant patient with BMI of 22 who is 1 year after double-lung transplant with neither elevated PRM measure (485.2 d; 1.3 yr).