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. 2021 Oct 11;10(10):2719. doi: 10.3390/cells10102719

Figure 1.

Figure 1

Effects of cycloastragenol against the elevated oxidative stress and altered expression of BDNF and p-TrkB in the Aβ-injected mice. (a,b) Graphical representation of LPO and ROS assays in vivo. (c) Western blot results of Nrf2, HO-1, p-TrkB, TrkB, and BDNF in the frontal cortex and hippocampus of the experimental mice, with respective bar graphs. (d) Immunofluorescence of BDNF and TrkB in the frontal cortex and hippocampus (CA1) of the experimental mice brain. The scale bar is 50 µm, green is BDNF, red is p-TrkB, and blue is DAPI for nuclear staining. The p-value <0.05 was considered a significant difference. * showing a significantly different from the control group; # significantly different from the Aβ-injected group. Significant difference = * p < 0.05; # p < 0.05. CAG20: Cycloastragenol 20 mg/kg, DAPI: 4′,6-diamidino-2-phenylindole, Aβ: Amyloid beta, CAG: Cycloastragenol, ns: non-significant difference.