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. 2021 Oct 11;10(10):2719. doi: 10.3390/cells10102719

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of cycloastragenol against the mitochondrial dysfunction in an Aβ-induced mouse model of Alzheimer’s disease. (a,b) Western blot results of Bax, Bcl-2, cleaved Caspase-3, and Bim in the experimental mice’s brains, with respective bar graphs. (c,d) Immunofluorescence analysis of Caspase-3 and Bim in the cortex and hippocampus of experimental mice, with respective bar graphs. The p-value < 0.05 was considered a significant difference. * showing a significantly different from the control group; # significantly different from the Aβ-injected group. Significance = * p < 0.05; # p < 0.05. CAG 20: Cycloastragenol 20 mg/Kg, Aβ: Amyloid beta, DAPI: 4′,6-Diamidino-2-phenylindole, CAG: Cycloastragenol, ns: non-significant difference.