Central metabolism of S. maltophilia D457. Schematic representation of the main pathways of the central metabolism: glycolysis (Entner-Doudoroff and Embden-Meyerhof-Parnas), tricarboxylic acid cycle, and glyoxylate cycle, pentose phosphate pathway, and anaplerotic and gluconeogenic reactions, as well as peripheral reactions. Underlined are the essential precursors for the biomass formation (40). The mutated enzyme in each FOS mutant is indicated with the name of the corresponding mutant. The abbreviations and names of substrates, products, and enzymes, as well as their locus tags, are shown in the legend to Fig. S3 in the supplemental material.