Table 1.
Effects of loganin on fasting blood glucose, fasting plasma insulin and HOMA-IR in PDN rats in week 4. All data are presented as means ± SEM. ** p < 0.01 vs. CTL group; # p < 0.05 vs. PDN group, ## p < 0.01 vs. PDN group, n = 8.
| Parameters | Groups | |||
|---|---|---|---|---|
| CTL | PDN | CTL + Loganin | PDN + Loganin | |
| Fasting blood glucose (mg/dL) | 120.5 ± 4.1 | 428.3 ± 21.0 ** | 118.3 ± 4.48 ## | 335.2 ± 41.1 **,# |
| Fasting plasma insulin (mIU/L) | 14.5 ± 0.68 | 13.1 ± 0.41 | 14.4 ± 0.75 | 13.2 ± 0.54 |
| HOMA-IR score | 3.84 ± 0.17 | 11.1 ± 0.36 ** | 4.05 ± 0.23 ## | 8.82 ± 0.8 **,# |
CTL: control, PDN: painful diabetic neuropathy, HOMA-IR, homeostasis model assessment-insulin resistance.