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. 2021 Oct 15;10(10):2759. doi: 10.3390/cells10102759
HSCs hepatic stellate cells
ECM extracellular matrix
NK natural killer
CCl4 carbon tetrachloride
TAA thioacetamide
BDL bile duct ligation
EMT epithelial-mesenchymal transition
MMPs matrix metalloproteases
KCs Kupffer cells
TIMPs tissue inhibitors of metalloproteases
LSECs liver sinusoidal endothelial cells
LOXL2 lysyl oxidase-like 2
RAS renin-angiotensin system
MSCs mesenchymal stem cells
cAMP cyclic adenosine monophosphate
PKA protein kinase A
CTGF connective tissue growth factor
OCA obeticholic acid
α-SMA α-smooth muscle actin
SLPI secretory leukocyte protease inhibitor
PGE2 prostaglandin E2
CSF-1R colony-stimulating factor 1 receptor
TG triacylglycerol
DAAs direct-acting antivirals
Hh Hedgehog
HIF hypoxia-inducible factor
IL interleukin
HCC hepatocellular carcinoma
VEGF vascular endothelial growth factor