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. 2021 Oct 8;10(10):2692. doi: 10.3390/cells10102692

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Overview of the morphological hallmarks characterizing whole-body regeneration in Nematostella. Confocal images of DAPI (nuclei in cyan) stained regenerating oral regions of juvenile Nematostella polyps (a–e) represent the characteristic phenotype of a given regeneration step. The panel spans 144 hours of regeneration and indicates the proliferation independent (steps 0, 1) and dependent (steps 2–4) steps of the process. The arrows below indicate the beginning of measurable tissular, cellular, and molecular events. The red dashed line indicates the amputation plane and the yellow arrow heads highlight tentacle buds/elongating tentacles; (m) mesenteries, (pha lip) pharyngeal lip, (pha) pharynx, (*) mouth opening (modified from [21,77,99]).