Table 2.

A summary of the detailed results from the pathway analysis for female patients. We tested many pathways at the same time, and the statistical p values from enrichment analysis were further adjusted for multiple testings. From the table, the “Total” in the table is the total number of compounds in the pathway; the “Hits” is the actually matched number from the user uploaded data; the “Raw p” is the original p value calculated from the enrichment analysis; the “Holm p” is the p value adjusted by Holm-Bonferroni method; the “FDR p” is the p value adjusted using false discovery rate; the “Impact” is the pathway impact value calculated from pathway topology analysis.

Metabolites	Total	Expected	Hits	Raw p	−log10(p)	Holm Adjust	FDR	Impact
Glycerophospholipid metabolism	36	0.37	3	5.24 × 10−3	2.28 × 100	4.40 × 10−1	4.40 × 101	0.25
Pantothenate and CoA biosynthesis	19	0.20	2	1.54 × 10−2	1.81 × 100	1.00 × 100	5.24 × 101	0.05
beta-Alanine metabolism	21	0.22	2	1.87 × 10−2	1.73 × 100	1.00 × 100	5.24 × 101	0.16
Linoleic acid metabolism	5	0.05	1	5.06 × 10−2	1.30 × 100	1.00 × 100	9.96 × 101	0.00
Pyrimidine metabolism	39	0.40	2	5.93 × 10−2	1.23 × 100	1.00 × 100	9.96 × 101	0.04
alpha-Linolenic acid metabolism	13	0.13	1	1.27 × 10−1	8.97 × 10−1	1.00 × 100	1.00 × 100	0.00
Glycerolipid metabolism	16	0.17	1	1.54 × 10−1	8.13 × 10−1	1.00 × 100	1.00 × 100	0.01
Selenocompound metabolism	20	0.21	1	1.88 × 10−1	7.25 × 10−1	1.00 × 100	1.00 × 100	0.00
Alanine, aspartate and glutamate metabolism	28	0.29	1	2.54 × 10−1	5.95 × 10−1	1.00 × 100	11.00 × 100	0.00
Phosphatidylinositol signaling system	28	0.29	1	2.54 × 10−1	5.95 × 10−1	1.00 × 100	1.00 × 100	0.00
Arachidonic acid metabolism	36	0.37	1	3.15 × 10−1	5.02 × 10−1	1.00 × 100	1.00 × 100	0.00
Biosynthesis of unsaturated fatty acids	36	0.37	1	3.15 × 10−1	5.02 × 10−1	1.00 × 100	1.00 × 100	0.00
Tryptophan metabolism	41	0.42	1	3.50 × 10−1	4.56 × 10−1	1.00 × 100	1.00 × 100	0.01
Aminoacyl-tRNA biosynthesis	48	0.50	1	3.97 × 10−1	4.01 × 10−1	1.00 × 100	1.00 × 100	0.00