Table A1.
List of included studies.
| Title | Journal | Year | Reference | |
|---|---|---|---|---|
| 1 | Transfer factor versus combination chemotherapy: a preliminary report of a randomized postsurgical adjuvant treatment study in osteogenic sarcoma. | Annals of the New York Academy of Sciences | 1976 | [34] |
| 2 | Irradiation of the lungs as an adjuvant therapy in the treatment of osteosarcoma of the limbs. An E.O.R.T.C. randomized study. | European journal of cancer | 1978 | [35] |
| 3 | Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate. A prospective, randomized evaluation. | Annals of internal medicine | 1979 | [36] |
| 4 | Ewing’s sarcoma of the vertebral column. | International journal of radiation oncology, biology, physics | 1981 | [37] |
| 5 | The role of radiation therapy in the management of non-metastatic Ewing’s sarcoma of bone. Report of the Intergroup Ewing’s Sarcoma Study. | International journal of radiation oncology, biology, physics | 1981 | [38] |
| 6 | Japanese experience with clinical trials of fast neutrons. | International journal of radiation oncology, biology, physics | 1982 | [39] |
| 7 | Toxicity associated with combination chemotherapy for osteosarcoma: a report of the cooperative osteosarcoma study (COSS 80). | Journal of cancer research and clinical oncology | 1983 | [40] |
| 8 | VM-26 and dimethyl triazeno imidazole carboxamide in Ewing’s sarcoma. | Australian paediatric journal | 1983 | [41] |
| 9 | Adjuvant chemotherapy in osteosarcoma-effects of cisplatinum, BCD, and fibroblast interferon in sequential combination with HD-MTX and adriamycin. Preliminary results of the COSS 80 study. | Journal of cancer research and clinical oncology | 1983 | [42] |
| 10 | The effect of adjuvant chemotherapy on relapse-free survival in patients with osteosarcoma of the extremity. | The New England journal of medicine | 1986 | [43] |
| 11 | Adriamycin-methotrexate high dose versus adriamycin-methotrexate moderate dose as adjuvant chemotherapy for osteosarcoma of the extremities: a randomized study. | European journal of cancer & clinical oncology | 1986 | [44] |
| 12 | A trial of chemotherapy in patients with osteosarcoma (a report to the Medical Research Council by their Working Party on Bone Sarcoma. | British journal of cancer | 1986 | [45] |
| 13 | A randomized study comparing high-dose methotrexate with moderate-dose methotrexate as components of adjuvant chemotherapy in childhood nonmetastatic osteosarcoma: a report from the Childrens Cancer Study Group. | Medical and pediatric oncology | 1987 | [46] |
| 14 | The relationship of various aspects of surgical management to outcome in childhood nonmetastatic osteosarcoma: a report from the Childrens Cancer Study Group. | Journal of pediatric surgery | 1988 | [47] |
| 15 | Platinum disposition after intraarterial and intravenous infusion of cisplatin for osteosarcoma. Cooperative Osteosarcoma Study Group COSS. | Cancer chemotherapy and pharmacology | 1989 | [48] |
| 16 | Limb sparing versus amputation in osteosarcoma. Correlation between local control, surgical margins and tumor necrosis: Istituto Rizzoli experience. | Annals of oncology: official journal of the European Society for Medical Oncology | 1992 | [49] |
| 17 | Granulocyte-macrophage-colony stimulating factor for prevention of neutropenia and infections in children and adolescents with solid tumors. Results of a prospective randomized study. | Cancer | 1995 | [50] |
| 18 | Radiation therapy in Ewing’s sarcoma: an update of the CESS 86 trial. | International journal of radiation oncology, biology, physics | 1995 | [51] |
| 19 | Intra-arterial versus intravenous cisplatinum (in addition to systemic Adriamycin and high dose methotrexate) in the neoadjuvant treatment of osteosarcoma of the extremities. results of a randomized study. | Journal of chemotherapy (Florence, Italy) | 1996 | [52] |
| 20 | Long-term follow-up and post-relapse survival in patients with non-metastatic osteosarcoma of the extremity treated with neoadjuvant chemotherapy. | Annals of oncology: official journal of the European Society for Medical Oncology | 1997 | [53] |
| 21 | Randomised trial of two regimens of chemotherapy in operable osteosarcoma: a study of the European Osteosarcoma Intergroup. | Lancet (London, England) | 1997 | [54] |
| 22 | A multidisciplinary study investigating radiotherapy in Ewing’s sarcoma: end results of POG #8346. Pediatric Oncology Group. | International journal of radiation oncology, biology, physics | 1998 | [55] |
| 23 | The pharmacokinetics and metabolism of ifosfamide during bolus and infusional administration: a randomized cross-over study. | British journal of cancer | 1998 | [56] |
| 24 | Ewing sarcoma of the rib: results of an intergroup study with analysis of outcome by timing of resection. | The Journal of thoracic and cardiovascular surgery | 2000 | [57] |
| 25 | Osteosarcoma in preadolescent patients. | Clinical orthopaedics and related research | 2000 | [58] |
| 26 | Granisetron, tropisetron, and ondansetron in the prevention of acute emesis induced by a combination of cisplatin-Adriamycin and by high-dose ifosfamide delivered in multiple-day continuous infusions. | Supportive care in cancer: official journal of the Multinational Association of Supportive Care in Cancer | 2000 | [59] |
| 27 | The possible cost effectiveness of peripheral blood stem cell mobilization with cyclophosphamide and the late addition of G-CSF. | Journal of Korean medical science | 2000 | [60] |
| 28 | Second malignancies after ewing tumor treatment in 690 patients from a cooperative German/Austrian/Dutch study. | Annals of oncology: official journal of the European Society for Medical Oncology | 2001 | [61] |
| 29 | A comparison of methods of loco-regional chemotherapy combined with systemic chemotherapy as neo-adjuvant treatment of osteosarcoma of the extremity. | European journal of surgical oncology: the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology | 2001 | [62] |
| 30 | Presurgical chemotherapy compared with immediate surgery and adjuvant chemotherapy for nonmetastatic osteosarcoma: Pediatric Oncology Group Study POG-8651. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2003 | [63] |
| 31 | Addition of ifosfamide and etoposide to standard chemotherapy for Ewing’s sarcoma and primitive neuroectodermal tumor of bone. | The New England journal of medicine | 2003 | [64] |
| 32 | Twenty-year follow-up of osteosarcoma of the extremity treated with adjuvant chemotherapy. | Journal of chemotherapy (Florence, Italy) | 2004 | [65] |
| 33 | Treatment of metastatic Ewing’s sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide—a Children’s Cancer Group and Pediatric Oncology Group study. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2004 | [66] |
| 34 | Extracorporeal focused ultrasound surgery for treatment of human solid carcinomas: early Chinese clinical experience. | Ultrasound in medicine & biology | 2004 | [67] |
| 35 | Osteosarcoma: a randomized, prospective trial of the addition of ifosfamide and/or muramyl tripeptide to cisplatin, doxorubicin, and high-dose methotrexate. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2005 | [68] |
| 36 | Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with recurrent/refractory sarcoma: the Children’s Cancer Group (CCG) experience. | Pediatric blood & cancer | 2005 | [69] |
| 37 | Local control in pelvic Ewing sarcoma: analysis from INT-0091—a report from the Children’s Oncology Group. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2006 | [70] |
| 38 | Contribution to the treatment of nausea and emesis induced by chemotherapy in children and adolescents with osteosarcoma. | Sao Paulo medical journal = Revista paulista de medicina | 2006 | [71] |
| 39 | Intensive therapy with growth factor support for patients with Ewing tumor metastatic at diagnosis: Pediatric Oncology Group/Children’s Cancer Group Phase II Study 9457—a report from the Children’s Oncology Group. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2006 | [72] |
| 40 | Pharmacokinetics and pharmacodynamics of intravenous epoetin alfa in children with cancer. | Pediatric blood & cancer | 2006 | [73] |
| 41 | Toxicity prevention with amifostine in pediatric osteosarcoma patients treated with cisplatin and doxorubicin. | Pediatric hematology and oncology | 2007 | [74] |
| 42 | SFOP OS94: a randomised trial comparing preoperative high-dose methotrexate plus doxorubicin to high-dose methotrexate plus etoposide and ifosfamide in osteosarcoma patients. | European journal of cancer (Oxford, England: 1990) | 2007 | [75] |
| 43 | Dexrazoxane-associated risk for acute myeloid leukemia/myelodysplastic syndrome and other secondary malignancies in pediatric Hodgkin’s disease. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | [76] | |
| 44 | Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: a randomized phase III trial of the European Osteosarcoma Intergroup. | Journal of the National Cancer Institute | 2007 | [77] |
| 45 | Therapy-related myelodysplasia and acute myeloid leukemia after Ewing sarcoma and primitive neuroectodermal tumor of bone: A report from the Children’s Oncology Group. | Blood | 2007 | [78] |
| 46 | Results of the EICESS-92 Study: two randomized trials of Ewing’s sarcoma treatment-cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2008 | [79] |
| 47 | Osteosarcoma: the addition of muramyl tripeptide to chemotherapy improves overall survival—a report from the Children’s Oncology Group. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2008 | [80] |
| 48 | Addition of muramyl tripeptide to chemotherapy for patients with newly diagnosed metastatic osteosarcoma: a report from the Children’s Oncology Group. | Cancer | 2009 | [81] |
| 49 | Dose-intensified compared with standard chemotherapy for nonmetastatic Ewing sarcoma family of tumors: a Children’s Oncology Group Study. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2009 | [82] |
| 50 | Phase I trial of cixutumumab combined with temsirolimus in patients with advanced cancer. | Clinical cancer research: an official journal of the American Association for Cancer Research | 2011 | [83] |
| 51 | Randomized controlled trial of interval-compressed chemotherapy for the treatment of localized Ewing sarcoma: a report from the Children’s Oncology Group. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2012 | [84] |
| 52 | Long-term results (>25 years) of a randomized, prospective clinical trial evaluating chemotherapy in patients with high-grade, operable osteosarcoma. | Cancer | 2012 | [85] |
| 53 | Neoadjuvant chemotherapy with methotrexate, cisplatin, and doxorubicin with or without ifosfamide in nonmetastatic osteosarcoma of the extremity: an Italian sarcoma group trial ISG/OS-1. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2012 | [86] |
| 54 | Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2014 | [87] |
| 55 | Does intensity of surveillance affect survival after surgery for sarcomas? Results of a randomized noninferiority trial. | Clinical orthopaedics and related research | 2014 | [88] |
| 56 | Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients with Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial. | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2015 | [89] |
| 57 | Impact of gender on efficacy and acute toxicity of alkylating agent -based chemotherapy in Ewing sarcoma: secondary analysis of the Euro-Ewing99-R1 trial. | European journal of cancer (Oxford, England: 1990) | 2015 | [90] |
| 58 | Local control in Ewing sarcoma of the chest wall: results of the EURO-EWING 99 trial. | Annals of surgical oncology | 2015 | [91] |
| 59 | Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. | The Lancet. Oncology | 2016 | [92] |
| 60 | Zoledronate in combination with chemotherapy and surgery to treat osteosarcoma (OS2006): a randomised, multicentre, open-label, phase 3 trial. | The Lancet. Oncology | 2016 | [93] |
| 61 | Glucagon Decreases IGF-1 Bioactivity in Humans, Independently of Insulin, by Modulating Its Binding Proteins. | The Journal of clinical endocrinology and metabolism | 2017 | [94] |
| 62 | Metronomic Chemotherapy vs. Best Supportive Care in Progressive Pediatric Solid Malignant Tumors: A Randomized Clinical Trial. | JAMA oncology | 2017 | [95] |
| 63 | Results of a randomized, prospective clinical trial evaluating metronomic chemotherapy in nonmetastatic patients with high-grade, operable osteosarcomas of the extremities: A report from the Latin American Group of Osteosarcoma Treatment. | Cancer | 2017 | [96] |
| 64 | The role of FDG PET/CT in patients treated with neoadjuvant chemotherapy for localized bone sarcomas. | European journal of nuclear medicine and molecular imaging | 2017 | [97] |
| 65 | Significance of neoadjuvant chemotherapy (NACT) in limb salvage treatment of osteosarcoma and its effect on GLS1 expression. | European review for medical and pharmacological sciences | 2018 | [98] |
| 66 | Ewing’s Sarcoma of the Head and Neck: Margins are not just for surgeons. | Cancer medicine | 2018 | [99] |
| 67 | Comprehensive Treatment and Rehabilitation of Patients with Osteosarcoma of the Mandible. | Implant dentistry | 2018 | [100] |
| 68 | Pantoprazole, an Inhibitor of the Organic Cation Transporter 2, Does Not Ameliorate Cisplatin-Related Ototoxicity or Nephrotoxicity in Children and Adolescents with Newly Diagnosed Osteosarcoma Treated with Methotrexate, Doxorubicin, and Cisplatin. | The Oncologist | 2018 | [101] |
| 69 | Gabapentin as an Adjuvant Therapy for Prevention of Acute Phantom-Limb Pain in Pediatric Patients Undergoing Amputation for Malignant Bone Tumors: A Prospective Double-Blind Randomized Controlled Trial. | Journal of pain and symptom management | 2018 | [102] |
| 70 | Results of methotrexate-etoposide-ifosfamide based regimen (M-EI) in osteosarcoma patients included in the French OS2006/sarcome-09 study. | European journal of cancer (Oxford, England: 1990) | 2018 | [103] |
| 71 | Efficacy and safety of regorafenib in adult patients with metastatic osteosarcoma: a non-comparative, randomised, double-blind, placebo-controlled, phase 2 study. | The Lancet. Oncology | 2019 | [104] |
| 72 | Effects of mindfulness-based stress reduction combined with music therapy on pain, anxiety, and sleep quality in patients with osteosarcoma. | Revista brasileira de psiquiatria (Sao Paulo, Brazil: 1999) | 2019 | [105] |
| 73 | Addition of Zoledronate to Chemotherapy in Patients with Osteosarcoma Treated with Limb-Sparing Surgery: A Phase III Clinical Trial. | Medical science monitor: international medical journal of experimental and clinical research | 2019 | [106] |