Table A3.
Studies with any domain with a high risk of bias rating.
| Study | Type of Sarcoma | Intervention | Journal | Year |
|---|---|---|---|---|
| Local control in pelvic Ewing sarcoma: analysis from INT-0091—a report from the Children’s Oncology Group. | Ewing Sarcoma | Medical | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2006 |
| Second malignancies after ewing tumor treatment in 690 patients from a cooperative German/Austrian/Dutch study. | Ewing Sarcoma | Medical | Annals of oncology: official journal of the European Society for Medical Oncology | 2001 |
| Randomised trial of two regimens of chemotherapy in operable osteosarcoma: a study of the European Osteosarcoma Intergroup. | Osteosarcoma | Medical | Lancet (London, England) | 1997 |
| Dexrazoxane-associated risk for acute myeloid leukemia/myelodysplastic syndrome and other secondary malignancies in pediatric Hodgkin’s disease. | Osteosarcoma | Medical | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2007 |
| Japanese experience with clinical trials of fast neutrons. | Osteosarcoma | Medical | International journal of radiation oncology, biology, physics | 1982 |
| Pharmacokinetics and pharmacodynamics of intravenous epoetin alfa in children with cancer. | Osteosarcoma | Medical | Pediatric blood & cancer | 2006 |
| Limb sparing versus amputation in osteosarcoma. Correlation between local control, surgical margins and tumor necrosis: Istituto Rizzoli experience. | Osteosarcoma | Surgical | Annals of oncology: official journal of the European Society for Medical Oncology | 1992 |
| Cyclophosphamide compared with ifosfamide in consolidation treatment of standard-risk Ewing sarcoma: results of the randomized noninferiority Euro-EWING99-R1 trial. | Ewing Sarcoma | Medical | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2014 |
| Contribution to the treatment of nausea and emesis induced by chemotherapy in children and adolescents with osteosarcoma. | Osteosarcoma | Medical | Sao Paulo medical journal = Revista paulista de medicina | 2006 |
| Improvement in histologic response but not survival in osteosarcoma patients treated with intensified chemotherapy: a randomized phase III trial of the European Osteosarcoma Intergroup. | Osteosarcoma | Medical | Journal of the National Cancer Institute | 2007 |
| Methotrexate, Doxorubicin, and Cisplatin (MAP) Plus Maintenance Pegylated Interferon Alfa-2b Versus MAP Alone in Patients with Resectable High-Grade Osteosarcoma and Good Histologic Response to Preoperative MAP: First Results of the EURAMOS-1 Good Response Randomized Controlled Trial. | Osteosarcoma | Medical | Journal of clinical oncology: official journal of the American Society of Clinical Oncology | 2015 |
| Comparison of MAPIE versus MAP in patients with a poor response to preoperative chemotherapy for newly diagnosed high-grade osteosarcoma (EURAMOS-1): an open-label, international, randomised controlled trial. | Osteosarcoma | Medical | The Lancet. Oncology | 2016 |
| Effects of mindfulness-based stress reduction combined with music therapy on pain, anxiety, and sleep quality in patients with osteosarcoma. | Osteosarcoma | Medical | Revista brasileira de psiquiatria (Sao Paulo, Brazil: 1999) | 2019 |
| Zoledronate in combination with chemotherapy and surgery to treat osteosarcoma (OS2006): a randomised, multicentre, open-label, phase 3 trial. | Osteosarcoma | Medical | The Lancet. Oncology | 2016 |
| Does intensity of surveillance affect survival after surgery for sarcomas? Results of a randomized noninferiority trial. | Osteosarcoma | Medical | Clinical orthopaedics and related research | 2014 |