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. 2021 Oct 9;10(10):2706. doi: 10.3390/cells10102706
LUBAC Linear ubiquitin chain assembly complex
Met: methionine
NF-κB Nuclear factor-κB
HOIP HOIL-1L interacting protein
HOIL-1L large isoform of heme-oxidized iron regulatory protein2 (IRP2) ubiquitin ligase 1 L
IRP2: iron regulatory protein2
SHARPIN SHANK-associated RH domain-interacting protein
SHANK SH3 and multiple ankyrin repeat domains protein
DUBs deubiquitinating enzymes
OTULIN OTU deubiquitinase with linear linkage specificity
CYLD cylindromatosis
RING Really interesting new gene
RBR RING-in-between-RING
E1 ubiquitin activating enzyme
E2 ubiquitin-conjugating enzyme
E3 ubiquitin ligase
K lysine
Cys cysteine
UBAN UBD in ABIN proteins and NEMO
NEMO NF-κB-essential modulator
OPTN ABIN: A20-binding inhibitors of NF-κB
NZF Npl4-type zinc finger
ZF7 seventh zinc finger
TNFAIP3 tumor necrosis factor α-induced protein 3
IKK IκB kinase
SNPs Single-nucleotide polymorphisms
SLE systemic lupus erythematous
ALS amyotrophic lateral sclerosis
POAG primary open-angle glaucoma
SPATA2 spermatogenesis-associated 2
RHD Rel homology domain
TNF-α tumor necrosis factor α
CD40L CD40 ligand
TLRs Toll-like receptors
TNFR TNF-receptor
DD death domain
TRADD TNFR-associated death domain
RIPK1 receptor interacting serine/threonine-protein kinase 1
TRAF2 TNF-receptor associated factor 2
cIAP1/2 cellular inhibitor of apoptosis proteins 1 and 2
IκBα inhibitor of κBα
FADD FAS-associated death domain protein
LDD Linear ubiquitin chain determining domain
UBL ubiquitin-like
UBA ubiquitin-associated
LTMs LUBAC-tethering motifs
PUB PNGase/UBA or UBX
Ser Serine
Thr Threonine
RNF213 ring finger protein 213
MycBP2 MYC Binding Protein 2
LPS ipopolysaccharide
MALT1 mucosa-associated lymphoid tissue lymphoma translocation gene 1
Arg arginine
Gly glycine
DLBCL diffuse large B-cell lymphoma
ABC-DLBCL activated B-cell–like DLBCL
SCVs: Salmonella-containing vacuoles
cpdm chronic proliferative dermatitis in mice
ORAS OTULIN-related autoinflammatory syndrome
GCB-DLBCL germinal center B-cell–like DLBCL
RNA-seq RNA sequencing