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. 2021 Oct 11;10(10):2716. doi: 10.3390/cells10102716

Table 1.

Advantages and disadvantages of selected vaccine platforms.

Design Upscaling Re-Using Established GMP Conditions Theoretical Safety Concerns
Recombinant viral vector (adenovirus) Not easy To be optimized Not guaranteed Recombination/persistence/integration
ivt mRNA Easy Easy Guaranteed None
Proteins/
sugars
Not easy To be optimized Not guaranteed None
Inactivated viruses Easy To be optimized Not guaranteed None