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. 2021 Oct 15;10(10):2761. doi: 10.3390/cells10102761

Figure 1.

Figure 1

Age-related inflammation changes in the C57BL/6J mouse cochlea. (I) Cochleogram showing progressive OHC loss throughout the basilar membrane for different age groups of mice: young (n = 13), intermediate-aged (n = 20), and old (n = 4) mice. Note that OHC loss starts from the cochlear basal end. (II) The number of missing OHCs is significantly higher in older age groups compared to the younger groups (p < 0.0001). (III) ABR thresholds at 4 different frequencies show significantly higher thresholds for the older animal groups compared to the younger, baseline animals (p < 0.001). (IV) Total number of macrophages in the sensory epithelium decreases between three age groups: 1 month (n = 11), 3–5 months (n = 16), and 10–12 months (n = 4). (V) Macrophage-gram shows the number of macrophages in the basal region decreases with age at a higher rate compared to the apical and medial regions. (VI) The difference in microphage amount in the apex is significantly higher in aged animals (3–12 months) compared to the young animals (1 month) (p < 0.05). (VII) A significant reduction in basal macrophages is observed between the age groups (*** p < 0.001, ** p = 0.002, * p = 0.014). From Frye et al. [82], with permission from the publisher.