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. 2021 Oct 15;10(10):2761. doi: 10.3390/cells10102761

Figure 5.

Figure 5

Protective effects of aldosterone treatment on SGN and ABR thresholds. (I) Spiral ganglion neuron (SGN) counts between young adult mice (left panel), middle-aged mice without aldosterone treatment (21 months, middle panel), and middle-aged mice with aldosterone treatment (21 months, right panel) show treated animals having higher SGN densities compared to nontreated animals. Magnification: 20 × 1.6. The bar graphs on the right show the quantified SGN cell density with mean ± S.E.M. for each subject group (II). Wideband noise mean ABR thresholds of CBA/CaJ mice measured before aldosterone treatment and at 2 and 4 months following treatments show control mice have increased thresholds consistent with ARHL, while aldosterone-treated mice had more stable thresholds. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. From Frisina et al. [113] and Halonen et al. [111], with permission from the publishers.