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. 2021 Oct 8;11:679287. doi: 10.3389/fonc.2021.679287

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Copyright © 2021 Werner, Strobel, Lehnick and Rajan

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multivariate analysis of our patient cohort of nodal positive head and neck cancer patients undergoing primary chemoradiation shows that the NLR and SUV_max of nodal metastasis are predictive of disease-specific survival and overall survival. There was a significant correlation between NLR and SUV_max of the primary tumor but not between NLR and nodal SUV_max. Therefore, the NLR and SUV_max of nodal metastasis could be used in addition to the TNM-classification to improve survival prediction and support treatment decision making in nodal positive head and neck cancer patients.