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. 2021 Oct 14;10(10):2756. doi: 10.3390/cells10102756

Figure 1.

Figure 1

SCFA treatments reduces NTG-induced hyperalgesia and pain. NTG injection considerably decreases tail flick latency compared to sham mice (A). SCFA treatment of 30 mg/kg and 100 mg/kg significantly increases tail flick latency (A) and significantly increases latency time for pain reaction already after 30 min following NTG injection (B). NTG administration considerably increases the total time of rubbing in Phases I and II of the orofacial formalin test compared to the sham group. The highest doses of SCFA treatments meaningfully reduces face rubbing time in both phases (C,D). Time in light exposure decreases in NTG-injected mice, compared to the sham group (E), while the treatment with SCFAs significantly reduces photophobia (E). Data are representative of at least three independent experiments. One-way and two-way ANOVA test. *** p < 0.001 vs. sham; ### p < 0.001 vs. NTG. N = 10 mice/group for each technique.