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. 2021 Oct 14;10(10):2756. doi: 10.3390/cells10102756

Figure 2.

Figure 2

NTG-induced neurodegeneration in the trigeminal nucleus is attenuated by SCFA treatments. Cresyl violet staining shows alterations of the SpVC area in NTG-injected mice (B,B1,J) compared to the sham group (A,A1,J). Sumatriptan administration significantly reduces NTG damage in mice (C,C1,J). SCFA treatment, at the highest doses (E,E1,F,F1,H,H1,I,I1,J), appreciably restores the trigeminal neurons of the SpVC area in a more effective way than SCFAs at a dose of 10 mg/kg (D,D1–G,G1,J). Data are representative of at least three independent experiments. One-way ANOVA test. N.D.: Not Detectable; *** p < 0.001 vs. sham; # p < 0.05 vs. NTG; ## p < 0.01 vs. NTG; ### p < 0.001 vs. NTG. N = 10 mice/group for each technique.