Table 5.
Result from the molecular pathway analysis (main analysis).
| Attempted | Not Worth | ||||||
|---|---|---|---|---|---|---|---|
| ID | Description | p.adjust | q Value | ID | Description | p.adjust | q Value |
| R-HSA-112316 | Neuronal System | 5.07 × 10−6 | 4.83 × 10−6 | R-HSA-5576891 | Cardiac conduction | 1.04 × 10−5 | 9.97 × 10−6 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 3.78 × 10−4 | 3.60 × 10−4 | R-HSA-373752 | Netrin-1 signaling | 2.09 × 10−5 | 2.01 × 10−5 |
| R-HSA-112315 | Transmission across Chemical Synapses | 6.87 × 10−4 | 6.55 × 10−4 | R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 3.17 × 10−5 | 3.04 × 10−5 |
| R-HSA-977443 | GABA receptor activation | 1.46 × 10−2 | 1.39 × 10−2 | R-HSA-112316 | Neuronal System | 4.16 × 10−5 | 3.99 × 10−5 |
| R-HSA-350054 | NOTCH-HLH transcription pathway | 1.84 × 10−2 | 1.76 × 10−2 | R-HSA-445095 | Interaction between L1 and Ankyrins | 8.71 × 10−5 | 8.35 × 10−5 |
| R-HSA-373752 | Netrin-1 signaling | 2.50 × 10−2 | 2.38 × 10−2 | R-HSA-397014 | Muscle contraction | 9.81 × 10−5 | 9.41 × 10−5 |
| R-HSA-446728 | Cell junction organization | 2.70 × 10−2 | 2.58 × 10−2 | R-HSA-373760 | L1CAM interactions | 1.50 × 10−4 | 1.43 × 10−4 |
| R-HSA-1500931 | Cell-Cell communication | 3.27 × 10−2 | 3.12 × 10−2 | R-HSA-5083635 | Defective B3GALTL causes Peters-plus syndrome (PpS) | 5.91 × 10−4 | 5.67 × 10−4 |
| R-HSA-428542 | Regulation of commissural axon pathfinding by SLIT and ROBO | 3.75 × 10−2 | 3.57 × 10−2 | R-HSA-5173214 | O-glycosylation of TSR domain-containing proteins | 7.40 × 10−4 | 7.09 × 10−4 |
| R-HSA-418990 | Adherens junctions interactions | 3.75 × 10−2 | 3.57 × 10−2 | R-HSA-1650814 | Collagen biosynthesis and modifying enzymes | 2.40 × 10−3 | 2.30 × 10−3 |
| R-HSA-421270 | Cell-cell junction organization | 4.29 × 10−2 | 4.10 × 10−2 | R-HSA-1474244 | Extracellular matrix organization | 2.81 × 10−3 | 2.69 × 10−3 |
| Hurt | R-HSA-8948216 | Collagen chain trimerization | 3.18 × 10−3 | 3.05 × 10−3 | |||
| ID | Description | p.adjust | q Value | R-HSA-375165 | NCAM signaling for neurite out-growth | 3.18 × 10−3 | 3.05 × 10−3 |
| R-HSA-112316 | Neuronal System | 2.23 × 10−7 | 2.11 × 10−7 | R-HSA-983712 | Ion channel transport | 3.82 × 10−3 | 3.66 × 10−3 |
| R-HSA-5576891 | Cardiac conduction | 2.23 × 10−7 | 2.11 × 10−7 | R-HSA-3000178 | ECM proteoglycans | 8.98 × 10−3 | 8.61 × 10−3 |
| R-HSA-397014 | Muscle contraction | 2.49 × 10−6 | 2.36 × 10−6 | R-HSA-2022928 | HS-GAG biosynthesis | 9.01 × 10−3 | 8.64 × 10−3 |
| R-HSA-112315 | Transmission across Chemical Synapses | 4.62 × 10−4 | 4.37 × 10−4 | R-HSA-5578775 | Ion homeostasis | 9.01 × 10−3 | 8.64 × 10−3 |
| R-HSA-373760 | L1CAM interactions | 4.62 × 10−4 | 4.37 × 10−4 | R-HSA-936837 | Ion transport by P-type ATPases | 1.04 × 10−2 | 1.00 × 10−2 |
| R-HSA-445095 | Interaction between L1 and Ankyrins | 8.83 × 10−4 | 8.37 × 10−4 | R-HSA-5173105 | O-linked glycosylation | 1.49 × 10−2 | 1.43 × 10−2 |
| R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission | 1.60 × 10−3 | 1.52 × 10−3 | R-HSA-5576892 | Phase 0—rapid depolarization | 1.71 × 10−2 | 1.64 × 10−2 |
| R-HSA-5576892 | Phase 0—rapid depolarization | 2.02 × 10−3 | 1.92 × 10−3 | R-HSA-3906995 | Diseases associated with O-glycosylation of proteins | 1.89 × 10−2 | 1.81 × 10−2 |
| R-HSA-1474244 | Extracellular matrix organization | 4.49 × 10−3 | 4.26 × 10−3 | R-HSA-112315 | Transmission across Chemical Synapses | 1.90 × 10−2 | 1.82 × 10−2 |
| R-HSA-5578775 | Ion homeostasis | 5.64 × 10−3 | 5.34 × 10−3 | R-HSA-419037 | NCAM1 interactions | 2.28 × 10−2 | 2.18 × 10−2 |
| R-HSA-373752 | Netrin-1 signaling | 5.64 × 10−3 | 5.34 × 10−3 | R-HSA-1474290 | Collagen formation | 4.63 × 10−2 | 4.44 × 10−2 |
| R-HSA-5173105 | O-linked glycosylation | 4.12 × 10−2 | 3.90 × 10−2 | ||||