Table 2.

Publications of validation of STRmix™ models.

Focus of Validation	Reference
Ability of STRmix™ to deconvolute profiles and assign LRs that comport to manual interpretation and human expectation	[15]
Ability of STRmix™ to discriminate between donors and non-donors in database searches	[190]
Behaviour of STRmix™ to assign LRs when dealing with multiple replicates, different number of contributors, and assumed contributors	[163]
Sensitivity of LR produced by STRmix™ to different factors of uncertainty such as theta, relatedness of alternate DNA source and length of MCMC analysis	[171]
Tests to be performed when validating probabilistic genotyping, using STRmix™ as an example	[112]
Ability of individuals from different laboratories to standardise evaluations when using STRmix™	[33,53]
Ability of STRmix™ to reliably use peak height information in very low intensity profiles	[56,132,210]
Ability of STRmix™ to discriminate between donors and non-donors in large-scale Hd true tests, or using importance sampling	[59,60,190,200,212,213]
Sensitivity of STRmix™ model parameters to laboratory factors	[196,198]
Ability of STRmix™ to utilise information from profiles produced under different laboratory conditions within a single analysis	[155]
Effect of mixture complexity, allele sharing and contributor proportions on the ability STRmix™ to distinguish contributors from non-contributors	[54]
The ability of STRmix™ to identify common DNA donors in mixed samples	[25,159]
The sensitivity of LRs produced in STRmix™ to the choice of the number of contributors	[71,72,97]
Ability to use STRmix™ to resolve major components of mixtures	[72]
Testing the assumption of additivity of peak heights in STRmix™ models	[159,160]
Performance of the degradation model within STRmix™	[214]
The effect of relatedness of contributors to the STRmix™ analysis	[203,215]
Testing the calibration of LRs produced in STRmix™	[58]
Validation overviews of STRmix™	[205,216]
Comparison of STRmix™ to other probabilistic genotyping software	[41,43,112,217]