Table 1.
Frequency of BRCA1 and BRCA2 variants in large-scale germ line studies in childhood and adolescent malignancies.
| BRCA1 Variants | BRCA2 Variants | Ref | |
|---|---|---|---|
| Long Term Survivor Study | 14/4402 | 20/4402 | Qin et al. 2020 [59] |
| Osteosarcoma | 3/1440 | 8/1440 | Mirabello et al. 2020 [60] |
| Paediatric Glioma | 1/220 | 1/220 | Muskens et al. 2020 [61] |
| Rhabdomyosarcoma | 1/615 | 6/615 | Li et al. 2021 [65] |
| Paed and adol. non-Hodgkins Lymphoma | not included | 13/1380 | Wang et al. 2019 [67] |
| Medulloblastoma | - | 11/1022 | Waszak et al. 2018 [64] |