Table 4.
Alcohol Use = No | Alcohol Use = Yes | |||||||
---|---|---|---|---|---|---|---|---|
Controls (N = 1411) |
Cases (N = 261) |
OR (95% CI) | p Value | Controls (N = 260) |
Cases (N = 152) |
OR (95% CI) | p Value | |
rs1229984 | ||||||||
CC/CT | 647 (45.9) | 68 (43.3) | Ref. | Ref. | 112 (43.1) | 34 (44.2) | Ref. | Ref. |
TT | 764 (54.1) | 89 (56.7) | 1.11 (0.80–1.55) | 0.544 | 148 (56.9) | 43 (55.8) | 0.96 (0.57–1.60) | 0.867 |
rs671 | ||||||||
GG/AG | 1270 (90.0) | 211 (84.5) | Ref. | Ref. | 255 (98.1) | 142 (100.0) | Ref. | Ref. |
AA | 141 (10.0) | 39 (15.5) | 1.66 (1.13–2.43) | 0.010 * | 5 (1.9) | 0 (0.0) | 0.00 (0.00–) | 0.999 |
Recessive (AA/AG) | 755 (53.5) | 149 (59.4) | 1.27 (0.97–1.67) | 0.087 | 75 (28.8) | 53 (37.3) | 1.47 (0.95–2.27) | 0.082 |
rs7534676 | ||||||||
TT/TC | 253 (18.2) | 16 (7.3) | Ref. | Ref. | 56 (21.8) | 7 (5.6) | Ref. | Ref. |
CC | 1135 (81.8) | 203 (92.7) | 2.83 (1.67–4.79) | <0.001 * | 201 (78.2) | 117 (94.4) | 4.66 (2.06–10.55) | <0.001 * |
rs7554974 | ||||||||
CC/CT | 259 (18.5) | 19 (8.5) | Ref. | Ref. | 56 (21.8) | 7 (5.6) | Ref. | Ref. |
TT | 1139 (81.5) | 205 (91.5) | 2.45 (1.51–4.00) | <0.001 * | 201 (78.2) | 118 (94.4) | 4.70 (2.07–10.64) | <0.001 * |
rs7518631 | ||||||||
GG/GA | 260 (18.6) | 19 (8.5) | Ref. | Ref. | 56 (21.8) | 8 (6.3) | Ref. | Ref. |
AA | 1138 (81.4) | 204 (91.5) | 2.45 (1.51–4.00) | <0.001 * | 201 (78.2) | 118 (93.7) | 4.11 (1.89–8.92) | <0.001 * |
rs72936453 | ||||||||
AA/AT | 260 (18.6) | 19 (8.5) | Ref. | Ref. | 56 (21.8) | 8 (6.3) | Ref. | Ref. |
TT | 1138 (81.4) | 204 (91.5) | 2.45 (1.51–4.00) | <0.001 * | 201 (78.2) | 119 (93.7) | 4.14 (1.91–8.99) | <0.001 * |
rs17111068 | ||||||||
GG/GT | 178 (12.6) | 4 (2.0) | Ref. | Ref. | 32 (12.3) | 1 (0.9) | Ref. | Ref. |
TT | 1233 (87.4) | 195 (98.0) | 7.04 (2.58–19.18) | <0.001 * | 228 (87.7) | 109 (99.1) | 15.30 (2.06–113.42) | 0.008 * |
rs76655136 | ||||||||
TT/TC | 167 (11.8) | 6 (2.7) | Ref. | Ref. | 35 (13.5) | 5 (4.1) | Ref. | Ref. |
CC | 1244 (88.2) | 215 (97.3) | 4.81 (2.10–11.00) | <0.001 * | 225 (86.5) | 118 (95.9) | 3.67 (1.40–9.62) | 0.008 * |
rs10778364 | ||||||||
CC/CT | 586 (42.0) | 76 (32.8) | Ref. | Ref. | 107 (41.3) | 47 (34.3) | Ref. | Ref. |
TT | 808 (58.0) | 156 (67.2) | 1.49 (1.10–2.00) | 0.008 * | 152 (58.7) | 90 (65.7) | 1.35 (0.88–2.07) | 0.174 |
rs34200934 | ||||||||
GG/GT | 365 (26.6) | 42 (17.1) | Ref. | Ref. | 79 (30.9) | 32 (23.7) | Ref. | Ref. |
TT | 1007 (73.4) | 204 (82.9) | 1.76 (1.24–2.51) | 0.002 * | 177 (69.1) | 103 (76.3) | 1.44 (0.89–2.32) | 0.137 |
rs11636446 | ||||||||
AA/AC | 321 (22.8) | 36 (15.2) | Ref. | Ref. | 64 (24.7) | 27 (19.1) | Ref. | Ref. |
CC | 1086 (77.2) | 201 (84.8) | 1.65 (1.13–2.40) | 0.009 * | 195 (75.3) | 114 (80.9) | 1.39 (0.84–2.30) | 0.206 |
rs79071218 | ||||||||
TT/TC | 170 (12.0) | 7 (3.1) | Ref. | Ref. | 23 (8.8) | 5 (3.5) | Ref. | Ref. |
CC | 1241 (88.0) | 219 (96.9) | 4.29 (1.99–9.25) | <0.001 * | 237 (91.2) | 137 (96.5) | 2.66 (0.99–7.15) | 0.053 |
rs1975431 | ||||||||
AA/AC | 169 (12.0) | 7 (3.1) | Ref. | Ref. | 23 (8.8) | 4 (2.8) | Ref. | Ref. |
CC | 1242 (88.0) | 219 (96.9) | 4.26 (1.97–9.19) | <0.001 * | 237 (91.2) | 137 (97.2) | 3.32 (113–9.81) | 0.030 * |
rs28829404 | ||||||||
CC/CT | 163 (11.6) | 13 (5.7) | Ref. | Ref. | 39 (15.0) | 2 (1.5) | Ref. | Ref. |
TT | 1248 (88.4) | 216 (94.3) | 2.17 (1.21–3.89) | 0.009 * | 221 (85.0) | 130 (98.5) | 11.47 (2.73–48.29) | 0.001 * |
Cumulative risk alleles | ||||||||
<Median | 615 (46.3) | 14 (19.4) | Ref. | Ref. | 142 (56.6) | 8 (21.1) | Ref. | Ref. |
≥Median | 713 (53.7) | 58 (80.6) | 3.57 (1.97–6.47) | <0.001 * | 109 (43.4) | 30 (78.9) | 4.89 (2.15–11.08) | <0.001 * |
Abbreviations: OR: odds ratio; CI: confidence interval. Odds ratios (ORs) were calculated by unadjusted univariate analysis. The median number of cumulative risk alleles was 23. * p value < 0.05.