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. 2021 Sep 29;12(10):1547. doi: 10.3390/genes12101547

Table 4.

Associations between ALDH genes and nasopharyngeal carcinoma susceptibility after stratification for alcohol use.

Alcohol Use = No Alcohol Use = Yes
Controls
(N = 1411)
Cases
(N = 261)
OR (95% CI) p Value Controls
(N = 260)
Cases
(N = 152)
OR (95% CI) p Value
rs1229984
 CC/CT 647 (45.9) 68 (43.3) Ref. Ref. 112 (43.1) 34 (44.2) Ref. Ref.
 TT 764 (54.1) 89 (56.7) 1.11 (0.80–1.55) 0.544 148 (56.9) 43 (55.8) 0.96 (0.57–1.60) 0.867
rs671
 GG/AG 1270 (90.0) 211 (84.5) Ref. Ref. 255 (98.1) 142 (100.0) Ref. Ref.
 AA 141 (10.0) 39 (15.5) 1.66 (1.13–2.43) 0.010 * 5 (1.9) 0 (0.0) 0.00 (0.00–) 0.999
 Recessive (AA/AG) 755 (53.5) 149 (59.4) 1.27 (0.97–1.67) 0.087 75 (28.8) 53 (37.3) 1.47 (0.95–2.27) 0.082
rs7534676
 TT/TC 253 (18.2) 16 (7.3) Ref. Ref. 56 (21.8) 7 (5.6) Ref. Ref.
 CC 1135 (81.8) 203 (92.7) 2.83 (1.67–4.79) <0.001 * 201 (78.2) 117 (94.4) 4.66 (2.06–10.55) <0.001 *
rs7554974
 CC/CT 259 (18.5) 19 (8.5) Ref. Ref. 56 (21.8) 7 (5.6) Ref. Ref.
 TT 1139 (81.5) 205 (91.5) 2.45 (1.51–4.00) <0.001 * 201 (78.2) 118 (94.4) 4.70 (2.07–10.64) <0.001 *
rs7518631
 GG/GA 260 (18.6) 19 (8.5) Ref. Ref. 56 (21.8) 8 (6.3) Ref. Ref.
 AA 1138 (81.4) 204 (91.5) 2.45 (1.51–4.00) <0.001 * 201 (78.2) 118 (93.7) 4.11 (1.89–8.92) <0.001 *
rs72936453
 AA/AT 260 (18.6) 19 (8.5) Ref. Ref. 56 (21.8) 8 (6.3) Ref. Ref.
 TT 1138 (81.4) 204 (91.5) 2.45 (1.51–4.00) <0.001 * 201 (78.2) 119 (93.7) 4.14 (1.91–8.99) <0.001 *
rs17111068
 GG/GT 178 (12.6) 4 (2.0) Ref. Ref. 32 (12.3) 1 (0.9) Ref. Ref.
 TT 1233 (87.4) 195 (98.0) 7.04 (2.58–19.18) <0.001 * 228 (87.7) 109 (99.1) 15.30 (2.06–113.42) 0.008 *
rs76655136
 TT/TC 167 (11.8) 6 (2.7) Ref. Ref. 35 (13.5) 5 (4.1) Ref. Ref.
 CC 1244 (88.2) 215 (97.3) 4.81 (2.10–11.00) <0.001 * 225 (86.5) 118 (95.9) 3.67 (1.40–9.62) 0.008 *
rs10778364
 CC/CT 586 (42.0) 76 (32.8) Ref. Ref. 107 (41.3) 47 (34.3) Ref. Ref.
 TT 808 (58.0) 156 (67.2) 1.49 (1.10–2.00) 0.008 * 152 (58.7) 90 (65.7) 1.35 (0.88–2.07) 0.174
rs34200934
 GG/GT 365 (26.6) 42 (17.1) Ref. Ref. 79 (30.9) 32 (23.7) Ref. Ref.
 TT 1007 (73.4) 204 (82.9) 1.76 (1.24–2.51) 0.002 * 177 (69.1) 103 (76.3) 1.44 (0.89–2.32) 0.137
rs11636446
 AA/AC 321 (22.8) 36 (15.2) Ref. Ref. 64 (24.7) 27 (19.1) Ref. Ref.
 CC 1086 (77.2) 201 (84.8) 1.65 (1.13–2.40) 0.009 * 195 (75.3) 114 (80.9) 1.39 (0.84–2.30) 0.206
rs79071218
 TT/TC 170 (12.0) 7 (3.1) Ref. Ref. 23 (8.8) 5 (3.5) Ref. Ref.
 CC 1241 (88.0) 219 (96.9) 4.29 (1.99–9.25) <0.001 * 237 (91.2) 137 (96.5) 2.66 (0.99–7.15) 0.053
rs1975431
 AA/AC 169 (12.0) 7 (3.1) Ref. Ref. 23 (8.8) 4 (2.8) Ref. Ref.
 CC 1242 (88.0) 219 (96.9) 4.26 (1.97–9.19) <0.001 * 237 (91.2) 137 (97.2) 3.32 (113–9.81) 0.030 *
rs28829404
 CC/CT 163 (11.6) 13 (5.7) Ref. Ref. 39 (15.0) 2 (1.5) Ref. Ref.
 TT 1248 (88.4) 216 (94.3) 2.17 (1.21–3.89) 0.009 * 221 (85.0) 130 (98.5) 11.47 (2.73–48.29) 0.001 *
Cumulative risk alleles
 <Median 615 (46.3) 14 (19.4) Ref. Ref. 142 (56.6) 8 (21.1) Ref. Ref.
 ≥Median 713 (53.7) 58 (80.6) 3.57 (1.97–6.47) <0.001 * 109 (43.4) 30 (78.9) 4.89 (2.15–11.08) <0.001 *

Abbreviations: OR: odds ratio; CI: confidence interval. Odds ratios (ORs) were calculated by unadjusted univariate analysis. The median number of cumulative risk alleles was 23. * p value < 0.05.