Table 4. Multivariable logistic regression analysis on determinants of first-line antiretroviral treatment failure among HIV Patients on ART at Mettu Karl Specialized Hospital, South West Ethiopia, 2020.
| Variable | Category | Case (N = 113) | Control (N = 339) | COR (95% CI) | AOR (95% CI) |
|---|---|---|---|---|---|
| Baseline WHO clinical stage | Stage I and II | 53 (46.9%) | 234 (69.0%) | 1 | 1 |
| Stage III and IV | 60 (53.1%) | 105 (31.0%) | 2.523 (1.632, 3.899) | 1.909 (1.103, 3.305) * | |
| Baseline BMI | <18.5kg/m2 | 63 (55.8%) | 89 (26.3%) | 3.539 (2.272, 5.513) | 2.208 (1.257, 3.877) * |
| > = 18.5kg/m2 | 250 (73.7%) | 50 (44.2%) | 1 | 1 | |
| Baseline CD4 | <100 Cells/mm3 | 59(52.2%) | 69 (20.4%) | 4.275 (2.715, 6.732) | 3.016 (1.734, 5.246) * |
| > = 100Cells/mm3 | 54 (47.8%) | 270 (79.6%) | 1 | 1 | |
| TB co-infection | Yes | 46 (40.7%) | 65 (19.2%) | 2.894 (1.822, 4.596) | 1.855 (1.027, 3.353) * |
| No | 67 (59.3%) | 274 (80.8%) | 1 | 1 | |
| History of lost to follow up | Yes | 15 (13.3%) | 8 (2.4%) | 6.333(2.608, 15.378) | 3.235(1.096, 9.551) * |
| No | 98 (86.7%) | 331 (97.6%) | 1 | 1 | |
| Adherence status | Good | 37 (32.7%) | 240 (70.8%) | 1 | 1 |
| Fair | 18 (15.9%) | 65 (19.2%) | 1.796 (0.960, 3.360) | 1.322 (0.643, 2.716) | |
| Poor | 58 (51.3%) | 34 (10.0%) | 11.065(6.404, 19.118) | 7.597 (4.059, 14.219) * | |
| Disclosure status | Yes | 105 (92.9%) | 334 (98.5%) | 1 | 1 |
| No | 8 (7.1%) | 5 (1.5%) | 5.090 (1.630, 15.893) | 1.663 (0.460, 6.013) | |
| Time lag to initiate ART after diagnosis | Within the same month | 30 (26.5%) | 158 (46.6%) | 1 | 1 |
| One to twenty four months | 65 (57.5%) | 157 (46.3%) | 2.180 (1.342, 3.544) | 1.702 (0.928, 3.121) | |
| After twenty four months | 18 (15.9%) | 24 (7.1%) | 3.950 (1.913, 8.157) | 4.979 (2.039, 12.158) * |
*Statistically significant at p-value<0.05;
COR: Crude odds ratio; AOR: Adjusted odds ratio; CI: Confidence interval; 1: Reference category.