Table 1.

Transcription factors expression in various aneuploids.

Groups	Enriched TF	TF Location	Function	2LFvsCF	2LMvsCM	MFvsCF
All trisomy	ac	X	BHLH transcription factor; interacts antagonistically with the Notch signaling pathway; nervous system development	down	down	down
All trisomy	kay	3R	involved in multiple biological processes	up	up	up
Trisomy 2L	BEAF-32	2R	chromatin domain insulator function, gene regulation and genome organization	down	down	normal
Trisomy 2L	BtbVII	3L	embryonic/larval nervous system; extended germ band embryo	up	up	normal
Trisomy 2L	CG3328	2R	embryonic/larval garland cell; orthologous to human MYRF (myelin regulatory factor)	up	up	normal
Trisomy 2L	crp	2L	controls cellular branching of the terminal cells at the ends of tracheal tubes; a downstream target gene of Myc	up	up	normal
Trisomy 2L	pnr	3R	an activator of proneural achaete-scute complex genes; dorsal cell fate determination; nervous system development	up	up	normal
Trisomy female	ci	4	Zn-finger family TF; Hedgehog (Hh) signaling pathway; pattern formation and growth control; activator form needs hh	down	down	down
Trisomy female	Jra	2R	homologue of the mammalian transcription factor Jun; pleiotropic roles in the CNS; regulated by bsk	down	normal	down

Transcription factors are obtained from enrichment analysis of TF-binding motifs. This table lists the comparison groups, the TFs, the chromosomes that TFs located, the functions of candidate TFs, and the expression changes of the TFs in three kinds of aneuploidy.