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AMPK nucleo-cytoplasmic shuttling upon different stimulation. pAMPKs are more localized on the cytoplasm upon starvation, exercise, and during the day. Upon heat shock and oxidant exposure, AMPK undergoes nuclear localization in a dephosphorylated state. Arrow: distribution direction of total AMPK, white circle: Thr 172 phosphorylated AMPK, black circle: non phosphorylated AMPK, yellow channel: nucleoporin.
