Table 2.
The performance of ADHFE1, SDC2, and PPP2R5C for detection of CRC.
| Gene Name | ||||
|---|---|---|---|---|
| ADHFE1 | SDC2 | PPP2R5C | ADHFE1 + SDC2 + PPP2R5C | |
| Cutoff value 1 | 5.02 | 7.50 | 9.33 | Any one positive |
| Sensitivity (Positive number/case) 2 |
84.6% (11/13) |
69.2% (9/13) |
69.2% (9/13) |
84.6% (11/13) |
| Specificity (Positive number/control) 3 |
100% (13/13) |
92.3% (12/13) |
100% (13/13) |
92.3% (12/13) |
1 Cutoff values of methylation level are determined by AUC-ROC calculation. 2 The numbers in parentheses represent the CRC cases identified by hypermethylated gene/total CRC cases. 3 The numbers in parentheses represent that the control subject number was able to identify as normal/total control subjects.