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. 2021 Sep 24;12(10):1485. doi: 10.3390/genes12101485

Figure 2.

Figure 2

Composition of PRC2-type complexes. (A) PRC2 complexes are divided into two main groups, PRC2.1 and PRC2.2. Both groups contain at their core RBBP4 or RBBP7, EED, SUZ12, and a histone methyltransferase subunit EZH1 or EZH2 that catalyzes H3K27me3. The PRC2.1 complex contains a PALI or an EPOP subunit, and a PCL protein that recognize the H3K36me2/3 histone marks. The PRC2.2 complex contains AEBP2 protein and a JARID2 protein that recognize PRC1-mediated H2AK119ub. (B–D) Illustration of three major mechanisms for PRC2 recruitment. (B) Histone modifications can mediate PRC2.1 recruitment via H3K36me3 reader activity of PCL proteins. (C) Similar to PRC1, PRC2.1 complexes also display a DNA-based generic recruitment via PCL proteins winged-helix domain binding activity to genomic regions enriched for CpG islands. (D) PRC2 recruitment can also be mediated in a PRC1-dependent manner, through H2AK119ub reader activity of the core PRC2.2 subunit JARID2.