Table 5.
Clinical responses observed according to CYP2D6 status.
| CYP2D6 Phenotype (Response Prediction) | Total | |||||
|---|---|---|---|---|---|---|
| PM (Null/Nearly-zero) | IM (Decreased) | EM (Normal) | UM (Increased) | |||
| Clinical Responses Observed | Null/Nearly-zero 1 | 0 0.00% |
1 1.27% |
7 8.86% |
0 0.00% |
8
10.13% |
| Decreased 2 | 0 0.00% |
6 7.59% |
4 5.06% |
1 1.27% |
11
13.92% |
|
| Normal 3 | 2 2.53% |
16 20.25% |
25 31.65% |
4 5.06% |
47
59.49% |
|
| Increased 4 | 2 2.53% |
5 6.33% |
6 7.59% |
0 0.00% |
13
16.46% |
|
| Total | 4 5.06% |
28 35.44% |
42 53.16% |
5 6.33% |
79
100.00% |
|
| Coefficient of concordance Kappa: K= -0.0609 | ||||||
PM, Poor Metabolizer; UM, Ultra-fast Metabolizer; IM, Intermediate Metabolizer; EM, Extensive Metabolizer.
1: no response at 150 mg; 2: 1 or 2 follicles at 150 mg; 3: 1 or 2 follicles at 50 or 100 mg; 4: > 2 follicles at 50 mg.
Data in bold are the frequencies and percentages of the population.