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Mechanism of amplification of an IR/MAR-bearing circular plasmid. The IR/MAR plasmid is shown in red arrows. DMs, if pre-existed in the same cells, are shown in green, and the chromosome arm is shown in cyan. The processes in wild-type cells are indicated by black arrows, and the ones only in SIRT 1 knock-out cells are indicated by red arrows. Modified from Figure 7 of [44].
