Table 3.
Univariable and multivariable binary logistic regression model for the prediction of early tumor progression during FOLFIRINOX.
| Univariable | Multivariable | |||
|---|---|---|---|---|
| Variable | OR (95% CI) | p | OR (95% CI) | p |
| Stage of disease Resectable LAPC Metastatic |
Ref 1.31 (0.58–2.95) 1.87 (0.65–5.35) |
0.521 0.245 |
||
| CA19-9 at baseline (per 100 kU/L) |
1.00 (1.00–1.01) | 0.475 | ||
| miR-17-3p relative expression over reference miRNAs (per 1 × 10−2 increase) a |
1.39 (0.91–2.13) | 0.125 | ||
| miR-373-3p relative expression over reference miRNAs (per 1 × 10−2 increase) a |
2.62 (0.90–7.63) | 0.078 | 3.99 (1.10–14.49) | 0.035 |
| miR-194-5p relative expression over reference miRNAs (per 1 × 10−2 increase) b |
0.94 (0.87–1.00) | 0.065 | 0.91 (0.83–0.99) | 0.030 |
a In samples before the start of FOLFIRINOX, b in samples after one cycle of FOLFIRINOX. CA19-9 = carbohydrate antigen 19-9, CI = confidence interval, OR = odds ratio, miR/miRNA = microRNA, Ref = reference.