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NRF2 signaling in 9-month-old zebrafish livers. (A) Western blot of p-AKT and NRF2 expression in zebrafish livers (n = 8). (B) Gene expression of ho-1, nqo1, and cat (n = 6). *, p < 0.05, **, p < 0.01, ***, p < 0.001. Data represent the mean, and error bars represent SEM. NAFLD, non-alcoholic fatty liver disease; ND, normal diet; HFD, high fat diet; HEX, high-fat diet plus exercise.
