3. The relationships between each subgroup variable and risk of each of the main elements of the primary outcome measure in surgical arm.
| Subgroups | Perioperative stroke or death in surgery group | |||
| HR | (95% CI) | P | ||
| Predefined participant subgroups | ||||
| Sex (women versus men) | 1.50 | (1.14 to 1.97) | 0.004 | |
| Age | < 65 years | 1.00 | 0.78 | |
| 65 to 74 years | 0.99 | (0.76 to 1.32) | ||
| 75+ years | 0.83 | (0.49 to 1.41) | ||
| Time since last event | < 2 weeks | 1.00 | 0.69 | |
| 2 to 4 weeks | 1.22 | (0.78 to 1.90) | ||
| 4 to 12 weeks | 1.14 | (0.77 to 1.68) | ||
| > 12 weeks | 1.28 | (0.84 to 1.95) | ||
| Primary symptomatic event | Ocular only | 1.00 | < 0.001 | |
| Cerebral TIA | 2.62 | (1.68 to 4.09) | ||
| Stroke | 1.91 | (1.22 to 3.01) | ||
| Diabetes | 1.45 | (1.05 to 2.02) | 0.03 | |
| Irregular or ulcerated plaque | 1.37 | (1.03 to 1.82) | 0.03 | |
| Contralateral ICA occlusion | 2.21 | (1.33 to 3.67) | 0.002 | |
| Post‐hoc participant subgroups | ||||
| Duration of cerebral TIA | 1 hour or less | 1.00 | ||
| > 1 hour | 1.24 | (0.81 to 1.92) | 0.33 | |
| Previous TIA or stroke | 1.59 | (1.21 to 2.09) | 0.001 | |
| Myocardial infarction | 0.87 | (0.59 to 1.27) | 0.46 | |
| Angina | 0.67 | (0.47 to 0.97) | 0.03 | |
| Treated hypertension | 1.33 | (1.02 to 1.74) | 0.04 | |
| Treated hyperlipidaemia | 1.06 | (0.74 to 1.51) | 0.75 | |
| Smoking | 0.97 | (0.74 to 1.27) | 0.81 | |
HR: hazard ratio ICA: internal carotid artery TIA: transient ischaemic attack