ISRCTN97744893.

Study name	The 2nd European Carotid Surgery Trial (ECST‐2)
Methods	A multicentre, randomised, controlled, open, prospective clinical trial with blinded outcome assessment
Participants	People with symptomatic or asymptomatic atherosclerotic carotid artery stenosis (> 50%, NASCET criteria), suitable for revascularisation with 5‐year Carotid Artery Risk (CAR) Score indicating risk < 20%
Interventions	Immediate carotid revascularisation with modern optimised medical treatment or modern optimised medical treatment alone
Outcomes	Primary outcome: any stroke at any time, plus non‐stroke death occurring within 30 days of revascularisation Secondary outcome: ipsilateral stroke, myocardial infarction, TIA, or any hospitalisation for vascular disease during follow‐up
Starting date	March 2012
Contact information	Stroke Research Group Institute of Neurology, University College London, Box 6, The National Hospital, Queen Square London. WC1N 3BG, UK
Notes

TIA: transient ischaemic attack