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. 2021 Oct 12;22(20):10994. doi: 10.3390/ijms222010994

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Neferine reduced PMA/A23187-induced JNK (A), p38 (B), and ERK (C) activation in RBL-2H3 cells. RBL-2H3 cells were pretreated with different concentrations of neferine—1, 3, and 10 μM—for 20 min, and then the cells were treated with PMA/A23187 (20 nM/1 μM) for 30 min. Western blots were analyzed quantitatively. Values represent the mean ± SEM from the three independent experiments. ## p < 0.01 compared with the no-treatment condition, * p < 0.05, ** p < 0.01 compared with the only PMA/A23187 treatment condition.

Neferine reduced PMA/A23187-induced JNK (A), p38 (B), and ERK (C) activation in RBL-2H3 cells. RBL-2H3 cells were pretreated with different concentrations of neferine—1, 3, and 10 μM—for 20 min, and then the cells were treated with PMA/A23187 (20 nM/1 μM) for 30 min. Western blots were analyzed quantitatively. Values represent the mean ± SEM from the three independent experiments. ## p < 0.01 compared with the no-treatment condition, * p < 0.05, ** p < 0.01 compared with the only PMA/A23187 treatment condition.